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. these types of experiments are named mutation accumulation (MA) experiments (Elena and Lenski 2003; Lind and Andersson 2008; Brockhurst et al. 2010). it is currently doable to follow up MA

https://directorylandia.com/listings349702/the-greatest-guide-to-44-of-the-world-s-population-has-at-least-the-first-of-5-gene-mutations-and-every-gene-mutation-works-against-you